Association of cardiac amyloidosis with valvular heart diseases – a nationwide analysis

Abstract Background Association of cardiac amyloidosis (CA) with aortic stenosis (AS) is well known. There limited data on the association CA other valvular heart diseases like regurgitation (AR), mitral (MS), (MR), tricuspid (TS), (TR), pulmonary (PS) and (PR). Purpose To assess associations between amyloidosis. Methods This a retrospective observational study from hospitalizations January 1, 2016, December 31, 2019, using National Inpatient Sample (NIS), largest all-payer public database hospital care in United States. We looked into (VHD) CA. Results From 2016 to total 4999 patients history CA, 16,711 MS, 361,864 MR, 380,072 AS, 89,452 AR, 194 TS, 104,151 TR, 853 PS, 13,277 PR were identified. Compared those without any had significantly higher MR (6.4% vs 1.3%, p<0.001), AS (3.6% AR (1% 0.3%, TS (0.02% 0, p<0.033), TR (2.7% 0.4%, (0.4% 0.1%, p<0.001). Mean age MS (73.7 years), (75.2 (81.4 (77.1 (82 (77.3 (78.1 years). males, females incidence (0.1% 0.03%, p<0.001) lower (1.2% 1.6%, (0.3% Conclusion was TR. Comparatively, younger than VHD. Funding Acknowledgement Type funding sources: None.