Association of autonomic dysfunction and clozapine

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Association of autonomic dysfunction and mild obstructive sleep apnea.

BACKGROUND Autonomic dysfunction (AD) has been independently associated with obstructive sleep apnea (OSA). Autonomic abnormalities are generally considered to be secondary to OSA. Autonomic dysfunction may also contribute to OSA. If AD contributes to OSA, we postulated that abnormalities may be present in mild OSA where the confounding causal effects of hypoxemia and sleep disruption are reduc...

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Clozapine-Induced Cardiovascular Side Effects and Autonomic Dysfunction: A Systematic Review

Background: Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia and has minimal risk for extrapyramidal symptoms. Therapeutic benefits, however, are accompanied by a myriad of cardiometabolic side-effects. The specific reasons for clozapine’s high propensity to cause adverse cardiometabolic events remain unknown, but it is believed that autonomic dysfunction may play ...

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ژورنال

عنوان ژورنال: British Journal of Psychiatry

سال: 2001

ISSN: 0007-1250,1472-1465

DOI: 10.1192/bjp.179.2.167