Association of aspartate aminotransferase in statin-induced rhabdomyolysis
نویسندگان
چکیده
منابع مشابه
Statin-Induced Rhabdomyolysis.
Rhabdomyolysis is syndrome characterized by muscle necrosis which causes the release of myoglobin into the bloodstream. The manifestations of this syndrome range from asymptomatic elevation of muscle enzymes to life-threatening cases associated with extremely high enzyme levels, electrolyte imbalance and acute renal failure. Symptoms of rhabdomyolysis include dark urine, muscle weakness and fat...
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Background The VEGF inhibitor pazopanib is a widely used first-line therapy for the treatment of advanced renal cell carcinoma. Potential drug-drug interactions and toxicities may be underrecognized. Case Presentation A 73-year-old woman with metastatic renal cell carcinoma on treatment with pazopanib presented with progressive inability to ambulate. The initial concern was for metastasis to ...
متن کاملPhotoinactivation of aspartate aminotransferase.
The cofactor pyridoxal 5’-phosphate bound through an aldimine linkage to lysine residues of the enzyme aspartate amiuotransferase is very stable to irradiation with light of 420 nm. The catalytic function of the enzyme exposed to light absorbed by the cofactor remains unaffected, indicating that pyridoxal 5’-phosphate is not an efficient active site photosensitizer for this aminotransferase. Th...
متن کاملAcylation of aspartate aminotransferase.
1. Acetylation of aspartate aminotransferase from pig heart inhibits completely the enzymic activity when the coenzyme is in the amino form (pyridoxamine phosphate) or when the coenzyme has been removed, but not when the coenzyme is in the aldehyde form (pyridoxal phosphate). 2. The group the acylation of which is responsible for the inhibition has been identified with the in-amino group of a l...
متن کاملExertion-induced rhabdomyolysis in a patient on statin therapy.
Sir, We describe a patient on long-term statin treatment who developed acute renal failure (ARF) from rhabdomyolysis following severe unaccustomed exertion. Reviewing the available literature, we did not find reports of exertioninduced rhabdomyolysis and ARF requiring dialysis while on statins. A 57-year-old male, with hypertension and hyperlipidaemia (on ramipril 2.5mg, atorvastatin 10mg daily...
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ژورنال
عنوان ژورنال: Journal of Primary Health Care
سال: 2017
ISSN: 1172-6156
DOI: 10.1071/hc17051