Association of Antibody-Dependent Neutrophil Phagocytosis With Distinct Antibody Glycosylation Profiles Following Typhoid Vaccination
نویسندگان
چکیده
Typhoid Vi-conjugate vaccines (Vi-TCV) have been developed to control typhoid fever in children endemic regions. Previously, a human challenge model of typhoid, Vi-TCV was administered prior deliberate ingestion Salmonella Typhi by healthy adult volunteers the UK. Vi-specific antibody-dependent neutrophil phagocytosis (ADNP) associated with protection against enteric this model, but it is not known if ADNP induced vaccination children. We measured cohort Nepalese receiving field study investigate whether functional antibody responses were also present an setting. Furthermore, we investigated relationships between measures and other properties response, including Vi-IgG IgA titres, Fc region glycosylation. Antibody-dependent significantly increased aged 9 months 15 years day 28 days following administration (D28). The magnitude comparable levels plasma from vaccinated UK adults. Neither IgG nor titres correlated scores at D28; however, vaccine-induced decreased IgG1 sialylation. These data suggest that produces children, which associate specific glycosylation patterns region.
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Correction: Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination
[This corrects the article DOI: 10.1371/journal.ppat.1005456.].
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ژورنال
عنوان ژورنال: Frontiers in tropical diseases
سال: 2021
ISSN: ['2673-7515']
DOI: https://doi.org/10.3389/fitd.2021.742804