Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection
نویسندگان
چکیده
منابع مشابه
EWI-2 association with α-actinin regulates T cell immune synapses and HIV viral infection.
EWI motif-containing protein 2 (EWI-2) is a member of the Ig superfamily that links tetraspanin-enriched microdomains to the actin cytoskeleton. We found that EWI-2 colocalizes with CD3 and CD81 at the central supramolecular activation cluster of the T cell immune synapse. Silencing of the endogenous expression or overexpression of a cytoplasmic truncated mutant of EWI-2 in T cells increases IL...
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ژورنال
عنوان ژورنال: BMC Medicine
سال: 2020
ISSN: 1741-7015
DOI: 10.1186/s12916-020-01529-6