Association between the aspartic acid D-repeat polymorphisms and osteoarthritis susceptibility
نویسندگان
چکیده
منابع مشابه
Association between asporin gene aspartic acid repeat polymorphism and osteoarthritis: an updated meta-analysis
Objective: Osteoarthritis (OA) is a common disease characterized by progressive degeneration of articular cartilage. Several studies have been performed to evaluate the association between asporin gene aspartic acid repeat (ASPN D-Repeat) polymorphism and osteoarthritis susceptibility, but produced conflicting results. Our aim is to determine whether ASPN D-repeat polymorphism is associated wit...
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BACKGROUND Osteoarthritis (OA) is a common chronic disease of the joints. Genetic factors may play a role in its development, and polymorphisms in the estrogen receptor alpha gene (ERα) have been associated with OA. However, previous studies into this relationship have reported inconsistent results, so we aimed to systematically review the association between ERα polymorphisms and OA susceptibi...
متن کاملMeta-analysis of association between the ASPN D-repeat and osteoarthritis.
Osteoarthritis (OA) is the most common form of human arthritis. Genetic factors have been implicated in OA. It was reported that an aspartic acid (D)-repeat polymorphism in the gene encoding asporin (ASPN) was associated with OA of knee and hip joints in Japanese; in the three independent studies performed, the D14 allele of the ASPN polymorphism was over-represented and the D13 allele was unde...
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Glutathione S-transferases (GSTs; EC: 2.5.1.18) are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. Functional genetic polymorphisms in genes encoding GSTM1 (a member of GST class mu; OMIM: 138350), and GSTT1 (a member of GST class theta; OMIM: 600436) have been well defined. The functional null alleles of GSTM1 and GSTT1 represent deletions of GSTM1 and GS...
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ژورنال
عنوان ژورنال: Medicine
سال: 2018
ISSN: 0025-7974,1536-5964
DOI: 10.1097/md.0000000000013163