Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

Recent studies report that individuals with polymorphisms in the genes encode for interleukin (IL)-1α and IL-1β (IL-1A IL1B, respectively) IL-1 receptor antagonist (IL-1RN) may be more susceptible developing peri-implantitis. Therefore, current systematic review evaluates what is reported about role of genetics, specifically single nucleotide (SNP) on variable number tandem repeats (VNTR) IL-1RN, development This was carried out by screening PubMed, B-on, Cochrane Scopus databases, articles English, Spanish, Portuguese, no limit regarding publication year. Eight were selected four meta-analytic syntheses. Our results show although there a lack consensus literature, seems to an association between IL-1A, IL-1B, IL-1RN The meta-analysis showed patients who have polymorphic allele at position +3954 IL-1B gene average almost twice risk peri-implantitis (odds ratio = 1.986, 95% confidence interval).