Assessment of Visual Function in Patients With Gyrate Atrophy Who Are Considered Candidates for Gene Replacement
نویسندگان
چکیده
منابع مشابه
Assessment of visual function in patients with gyrate atrophy who are considered candidates for gene replacement.
OBJECTIVE To assess the course of change of visual function outcome variables in 5 patients with gyrate atrophy before a gene replacement therapy clinical trial. METHODS The outcome variables selected were visual field sensitivity and electroretinogram amplitude. The course of change of these outcome variables was determined by calculation of their half-lives. RESULTS In the 4 to 6 years du...
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متن کاملExpression defect of ornithine aminotransferase gene in gyrate atrophy.
A generalized deficiency in the mitochondrial enzyme, ornithine aminotransferase (OAT: EC 2.6.1.13), is the hallmark of gyrate atrophy (GA), a hereditary degenerative disease of the choroid and retina of the eye that leads to blindness. A human OAT cDNA, previously constructed and characterized in our laboratory, and anti-human OAT antibody were used as probes to examine the OAT gene, mRNA and ...
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ژورنال
عنوان ژورنال: Archives of Ophthalmology
سال: 2001
ISSN: 0003-9950
DOI: 10.1001/archopht.119.5.667