Assessment of the antibacterial effect of Khaya senegalensis on some Gram-negative bacteria

Abstract Background The matter of antimicrobial resistance evokes the urgency to explore alternatives antibiotics traditionally used for microbial infections. This study aimed elucidate mechanism action antibacterial effect Khaya senegalensis liable bacterial strains responsible diarrheal Results data collected indicate that tested ( Salmonella Typhimurium ATCC 14028, Escherichia coli 25922, Shigella spp. and spp.) were sensitive extracts (Desr.) A.Juss. (aqueous hydro-ethanol) varying degrees. hydro-ethanolic extract was active on all with a MIC 25 mg/mL coupled bactericidal effect. aqueous only strain. Membrane permeability test show affect by attacking stability their outer membrane. potential indicated high percentage membrane destabilization bacteria is significantly p < 0.05) better than cefixime as reference. Conclusion revealed destroys Gram-bacteria cytoplasmic These provide first time mode concerning activity.