Assessment of long-term plasma exchange for familial hypercholesterolaemia.
نویسندگان
چکیده
منابع مشابه
Assessment of long-term plasma exchange for familial hypercholesterolaemia.
The effectiveness of repeated plasma exchange with 2 to 4 litres of plasma protein fraction as long-term treatment for familial hypercholesterolaemia has been evaluated in six severely affected patients receiving conventional cholesterol lowering treatment. Cell-separator mediated exchange at monthly intervals for one to two years reduced mean serum cholesterol levels from 18.5 mmol/l (715 mg/d...
متن کاملImproved survival of patients with homozygous familial hypercholesterolaemia treated with plasma exchange.
Plasma exchange was undertaken in five patients with homozygous familial hypercholesterolaemia at intervals of two weeks for a mean of 8.4 years. These patients had survived an average of 5.5 years longer than their five respective homozygous siblings (p = 0.3), each of whom must have had a matching genetic defect but who died untreated. The 37% decrease in peak serum cholesterol concentrations...
متن کاملEfficacy of statins in familial hypercholesterolaemia: a long term cohort study
OBJECTIVE To determine the efficacy of statin treatment on risk of coronary heart disease in patients with familial hypercholesterolaemia. DESIGN Cohort study with a mean follow-up of 8.5 years. SETTING 27 outpatient lipid clinics. SUBJECTS 2146 patients with familial hypercholesterolaemia without prevalent coronary heart disease before 1 January 1990. MAIN OUTCOME MEASURES Risk of coro...
متن کاملLong term statin treatment reduces lipoprotein(a) concentrations in heterozygous familial hypercholesterolaemia.
BACKGROUND Raised plasma lipoprotein(a) (Lp(a)) is associated with increased risk of cardiovascular disease. It is unknown whether increased Lp(a) is an additional risk factor for coronary artery disease in familial hypercholesterolaemia (FH) or whether statin treatment can reduce Lp(a) concentrations in the long term. OBJECTIVE To investigate Lp(a) concentrations in relation to statin treatm...
متن کاملLong-term experience (6 years) with simvastatin in patients with heterozygous familial hypercholesterolaemia.
OBJECTIVE To study the long-term efficacy and safety of the cholesterol synthesis inhibitor, simvastatin, in the treatment of familial hypercholesterolaemia. METHODS This is an open long-term follow-up of patients treated for 5 years or more in the Nijmegen University lipid clinic. Forty-four patients with heterozygous familial hypercholesterolaemia (mean baseline serum cholesterol level 11.5...
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ژورنال
عنوان ژورنال: Heart
سال: 1980
ISSN: 1355-6037
DOI: 10.1136/hrt.43.6.680