Assessment of Iron Overload and Role of Genetic Modifiers in Patients with Beta Thalassemia Intermedia
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چکیده
منابع مشابه
Endocrine Dysfunctions in Iron Overload in Patients with Major Thalassemia
Abstract Background The aim of the present study was to determine the endocrine dysfunction in patients with major thalassemia, who receive hyper transfusion. Materials and Methods This cross sectional study was performed during one year, which included 65 major thalassemia patients (31 females and 34 males), aged between 14 month to 27 years old (median 10,3). Growth assessment was measur...
متن کاملIron overload in Beta thalassaemia major and intermedia patients.
ABSTRACT BACKGROUND In beta thalassaemia major multiple blood transfusions, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body. Iron overload impairs the immune system, placing patients at greater risk of infection and illness. Iron overload can be determined by serum ferritin measurement. OBJECTIVE The aim of the present study is to...
متن کاملIRON OVERLOAD IN BETA THALASSEMIA – A Review
Due to improvements in transfusion therapy in beta-thalassemia major patients, transfusional hemosiderosis has now become the major cause of late morbidity and mortality in them. In India and other developing countries, iron chelation therapy is still not strictly adhered to in these children, mostly due to financial constraints. An orally effective and cheap iron chelator is the need of the ho...
متن کاملDual-echo TFE MRI for the assessment of myocardial iron overload in beta-thalassemia major patients.
PURPOSE Cardiac failure due to myocardial iron overload is the most common cause of death in beta-thalassemia patients. Multi/ two echo times-turbo field echo (TE-TFE) magnetic resonance imaging (MRI) is considered the gold standard technique in the evaluation of myocardial iron accumulation. However, multi TE-TFE technique is not available in all scanners. The aim of our study was to show the ...
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ژورنال
عنوان ژورنال: Pediatric Hematology Oncology Journal
سال: 2019
ISSN: 2468-1245
DOI: 10.1016/j.phoj.2019.08.110