Assessing the Accuracy of Ancestral Protein Reconstruction Methods
نویسندگان
چکیده
منابع مشابه
Assessing the Accuracy of Ancestral Protein Reconstruction Methods
The phylogenetic inference of ancestral protein sequences is a powerful technique for the study of molecular evolution, but any conclusions drawn from such studies are only as good as the accuracy of the reconstruction method. Every inference method leads to errors in the ancestral protein sequence, resulting in potentially misleading estimates of the ancestral protein's properties. To assess t...
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15 صفحه اولAncestral protein reconstruction: techniques and applications.
Ancestral sequence reconstruction (ASR) is the calculation of ancient protein sequences on the basis of extant ones. It is most powerful in combination with the experimental characterization of the corresponding proteins. Such analyses allow for the study of problems that are otherwise intractable. For example, ASR has been used to characterize ancestral enzymes dating back to the Paleoarchean ...
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Ancestral reconstruction is the extrapolation back in time from measured characteristics of individuals (or populations) to their common ancestors. It is an important application of phylogenetics, the reconstruction and study of the evolutionary relationships among individuals, populations, or species to their ancestors. In the context of biology, ancestral reconstruction can be used to recover...
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Choosing an ancestral state reconstruction method among the alternatives available for quantitative characters may be puzzling. We present here a comparison of seven of them, namely the maximum likelihood, restricted maximum likelihood, generalized least squares under Brownian, Brownian-with-trend and Ornstein-Uhlenbeck models, phylogenetic independent contrasts and squared parsimony methods. A...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2006
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.0020069