Assembly of the Mitochondrial Protein Import Channel
نویسندگان
چکیده
منابع مشابه
Assembly of the Mitochondrial Protein Import Channel
The preprotein translocase of the outer mitochondrial membrane (TOM) consists of a central β-barrel channel, Tom40, and six proteins with α-helical transmembrane segments. The precursor of Tom40 is imported from the cytosol by a pre-existing TOM complex and inserted into the outer membrane by the sorting and assembly machinery (SAM). Tom40 then assembles with α-helical Tom proteins to the matur...
متن کاملMitochondrial protein synthesis, import, and assembly.
The mitochondrion is arguably the most complex organelle in the budding yeast cell cytoplasm. It is essential for viability as well as respiratory growth. Its innermost aqueous compartment, the matrix, is bounded by the highly structured inner membrane, which in turn is bounded by the intermembrane space and the outer membrane. Approximately 1000 proteins are present in these organelles, of whi...
متن کاملRegulated cycling of mitochondrial Hsp70 at the protein import channel.
Hsp70 of the mitochondrial matrix (mtHsp70) provides a critical driving force for the import of proteins into mitochondria. Tim44, a peripheral inner-membrane protein, tethers it to the import channel. Here, regulated interactions were found to maximize occupancy of the active, adenosine 5'-triphosphate (ATP)-bound mtHsp70 at the channel through its intrinsic high affinity for Tim44, as well as...
متن کاملThe mitochondrial protein import apparatus.
INTRODUCTION ..................................................................................... 331 THE PRECURSOR PROTEINS .................................................................... 332 Targeting Signals ................................................................................. 332 Translocation Competence ........................................................................
متن کاملAssembly of the mitochondrial protein import channel: role of Tom5 in two- stage interaction of Tom40 with the SAM complex
The preprotein translocase of the outer mitochondrial membrane (TOM) consists of a central -barrel channel, Tom40, and six proteins with -helical transmembrane segments. The precursor of Tom40 is imported from the cytosol by a pre-existing TOM complex and inserted into the outer membrane by the sorting and assembly machinery (SAM). Tom40 then assembles with -helical Tom proteins to the mature T...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2010
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e10-06-0518