Assembly of branched ubiquitin oligomers by click chemistry

Synthesis of organometallic PNA oligomers by click chemistry.

The facile side-specific insertion, on the solid phase, of one or two ferrocene moieties into peptide nucleic acid (PNA) oligomers by click chemistry is presented.

"Four-potential" ferrocene labeling of PNA oligomers via click chemistry.

The scope of the Cu(I)-catalyzed [2 + 3] azide/alkyne cycloaddition (CuAAC, click chemistry) as a key reaction for the conjugation of ferrocene derivatives to N-terminal functionalized PNA oligomers is explored herein (PNA: peptide nucleic acid). The facile solid-phase synthesis of N-terminal azide or alkyne-functionalized PNA oligomer precursors and their cycloaddition with azidoferrocene, eth...

Construction and assembly of branched Y-shaped DNA: "click" chemistry performed on dendronized 8-aza-7-deazaguanine oligonucleotides.

Branched DNA was synthesized from tripropargylated oligonucleotides by the Huisgen-Meldal-Sharpless cycloaddition using "stepwise and double click" chemistry. Dendronized oligonucleotides decorated with 7-tripropargylamine side chains carrying two terminal triple bonds were further functionalized with bis-azides to give derivatives with two terminal azido groups. Then, the branched side chains ...

The Self-Assembly of Gold Nanoparticles Through "Click" Chemistry

Alkyl surface modification of nanoporous silica SBA-15 by click chemistry to obtain triazole products

In this study, Santa Barbara Amorphous (SBA-15) mesoporous silica has been functionalized with aminopropyl groups that were converted to propargyl-bearing moieties through the reaction with propargyl bromide. The material then underwent an efficient Cu(I)-catalyzed azide alkyne click reaction with sodium azide in order to obtain the corresponding triazole products. The covalent modification of ...