منابع مشابه
Aspartame-induced apoptosis in PC12 cells.
Aspartame is an artificial sweetner added to many low-calorie foods. The safety of aspartame remains controversial even though there are many studies on its risks. In this study, to understand the physiological effects of trace amounts of artificial sweetners on cells, the effects of aspartame on apoptosis were investigated using a PC12 cell system. In addition, the mechanism of apoptosis induc...
متن کاملMorphine-induced apoptosis in PC12 cells: role of Bax and Bcl2
Introduction: It was reported that morphine could induce apoptosis in neurons. However, its specific mechanistic pathways remain elusive. The present study was undertaken to determine whether morphine could induce apoptosis in PC12 cells, a neuronal cell line, and the involvement of Bax and Bcl-2, as upstream factors of mitochondrial pathway. Methods: In an experimental study, the viabili...
متن کاملBerberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
Objective(s): Neurodegenerative diseases have been associated with glutamatergic dysfunction. Berberine, an isoquinoline alkaloid broadly present in different medicinal herbs, has been reported to have neuroprotective effect. In the present study, the effects of berberine against glutamate-induced oxidative damage and apoptosis were investigated. Materials and Methods: The cultured PC12 and N2a...
متن کاملSodium valproate ameliorates aluminum-induced oxidative stress and apoptosis of PC12 cells
Objective(s): According to recent studies, valproate shows some protection against oxidative stress (OS) induced by neurotoxins. Current investigation tried to determine the possible ameliorating effects of sodium valproate (SV) against aluminum (Al)-induced cell death, apoptosis, mitochondrial membrane potential (MMP), and OS in PC12 cells.Materials ...
متن کاملNonylphenol diethoxylate inhibits apoptosis induced in PC12 cells.
Nonylphenol and short-chain nonylphenol ethoxylates such as NP2 EO are present in aquatic environment as wastewater contaminants, and their toxic effects on aquatic species have been reported. Apoptosis has been shown to be induced by serum deprivation or copper treatment. To understand the toxicity of nonylphenol diethoxylate, we investigated the effects of NP2 EO on apoptosis induced by serum...
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ژورنال
عنوان ژورنال: Environmental Toxicology and Pharmacology
سال: 2014
ISSN: 1382-6689
DOI: 10.1016/j.etap.2013.11.021