ASDB: a resource for probing protein functions with small molecules

ASDB: a resource for probing protein functions with small molecules

UNLABELLED : Identifying chemical probes or seeking scaffolds for a specific biological target is important for protein function studies. Therefore, we create the Annotated Scaffold Database (ASDB), a computer-readable and systematic target-annotated scaffold database, to serve such needs. The scaffolds in ASDB were derived from public databases including ChEMBL, DrugBank and TCMSP, with a scaf...

Probing microRNA network with small molecules

MicroRNAs (miRNAs) are emerging as novel regulators in gene expression. Due to the large population of miRNAs and their important function inside cells, miRNA network is essential for normal physiology but still remains unclear. Recent results also showed miRNAs are closely related with the occurrence and development of various human diseases. Thus, revealing miRNA network is urgently needed fo...

small molecules as protein-proteininteraction inhibitors

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INTERACTION OF PROTEINS WITH SMALL MOLECULES

Local Probing for Resource

This paper investigates a form of algorithm hybridization that combines constraint satisfaction algorithms with local search algorithms. On one hand, constraint satisfaction algorithms are eeective at nding feasible solutions for tightly constrained problems with complex constraints. On the other hand, local search algorithms are usually better at nding solutions that are good with respect to a...