Ascertainment and Prevention of Genetic Disease
نویسندگان
چکیده
منابع مشابه
phylogeography and genetic diversity of the lesser mouse- eared bat (myotis blythii) in iran
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Anticipation is the phenomenon whereby age of onset in genetic disease decreases in successive generations. Three independent reports have claimed anticipation in Creutzfeldt-Jakob disease (CJD) caused by the c.598G > A mutation in PRNP encoding a p.Glu200Lys (E200K) substitution in the prion protein. If confirmed, this finding would carry clear implications for genetic counseling. We analyzed ...
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Fisher (1934): "It is a statistical commonplace that the interpretation of a body of data requires knowledge of howi t wasobtained"-2-PREFACE This technical report consists of a preliminary version of a Chapter to be contributed to a text on Genetic Epidemiology,authored by Dr.T im Bishop, with others. Although the chapter can stand alone, some references are made to chapters by other authors. ...
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Family data are used extensively in quantitative genetic studies to disentangle the genetic and environmental contributions to various diseases. Many family studies based their analysis on population-based registers containing a large number of individuals composed of small family units. For binary trait analyses, exact marginal likelihood is a common approach, but, due to the computational dem...
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ژورنال
عنوان ژورنال: BMJ
سال: 1970
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.3.5723.636