منابع مشابه
Regulatory Control and the Costs and Benefits of Biochemical Noise
Experiments in recent years have vividly demonstrated that gene expression can be highly stochastic. How protein concentration fluctuations affect the growth rate of a population of cells is, however, a wide-open question. We present a mathematical model that makes it possible to quantify the effect of protein concentration fluctuations on the growth rate of a population of genetically identica...
متن کاملControl of internal and external noise in genetic regulatory networks.
Positive and negative feedback loops, for example, where a protein regulates its own transcription, play an important role in many genetic regulatory networks. Such systems will be subject to internal noise, which occurs due to the small number of molecules taking part in some reactions. This paper examines the effect of feedback loops on noise levels. Error growth techniques from nonlinear dyn...
متن کاملNoise Control in Gene Regulatory Networks with Negative Feedback.
Genes and proteins regulate cellular functions through complex circuits of biochemical reactions. Fluctuations in the components of these regulatory networks result in noise that invariably corrupts the signal, possibly compromising function. Here, we create a practical formalism based on ideas introduced by Wiener and Kolmogorov (WK) for filtering noise in engineered communications systems to ...
متن کاملAsa Options
Adaptive Simulated Annealing (ASA) is a C-language code that finds the best global fit of a nonlinear cost-function over a D-dimensional space. ASA has over 100 OPTIONS to provide robust tuning over many classes of nonlinear stochastic systems. These many OPTIONS help ensure that ASA can be used robustly across many classes of systems. Ke ywords: simulated annealing, nonlinear systems Most rece...
متن کاملNoise in Regulatory Networks 3
4 Abstract Gene regulatory networks control the production of the principal functional 5 units (proteins, RNA) in cells. The observation of variability in expression levels 6 within isogenic populations of cells demands an understanding of how this variability 7 changes our understanding of cellular behaviour inferred from bulk measurements. 8 In particular, we focus on simple models of gene ex...
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ژورنال
عنوان ژورنال: The Journal of the Acoustical Society of America
سال: 1992
ISSN: 0001-4966
DOI: 10.1121/1.404892