Arylation of 3-(2-furyl)-2-methylpropenal by arenediazonium salts
نویسندگان
چکیده
Arylfuran’s are an important class of compounds in practical terms. The availability and broad functionality arylfuran derivatives open wide opportunities for obtaining a significant variety potential biologically active substances. It is known that many have been found based on derivatives, moreover number drugs discovered. Functionalized furans, particular aldehydes the series, frequently used reagents organic synthesis especially creation combinatorial libraries screening biological activity. Taking all these into account, it obvious new functionalized furan with simple procedure urgent task. Herein we described arylation 3-(2-furyl)-2-methylpropenal arenediazonium salts. was established react salts to form products position 5 ring. Arylation carried out water-acetone medium presence catalyst – CuCl 2 . Thus reaction obtained yields up 49 %. Series 3-(5-aryl-2-furyl) methylacrylaldehydes condensed heterocycles contains moiety were prepared. best when dichloro-substituted while lowest case mono substituted rather low, but starting cheap commercially available reagents. Moreover, developed synthetic purification does not require use column chromatography. This circumstance makes possible scale desired 2-methyl-3-arylfurylacroleins multigram quantities. structure reliably confirmed using 1 H 13 C NMR spectroscopy. For prepared compounds, most characteristic signals spectra proton aldehyde group range 9.5–9.6 ppm ( NMR) carbon at 193–194 NMR). Keywords: arylfurans, arylation,
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ژورنال
عنوان ژورنال: Vìsnik L?vìvs?kogo unìversitetu
سال: 2023
ISSN: ['2078-5615']
DOI: https://doi.org/10.30970/vch.6401.249