Artificial surfactant therapy for hyaline membrane disease.
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چکیده
منابع مشابه
Artificial surfactant therapy for hyaline membrane disease
The demonstration that the lungs of infants who died with hyaline membrane disease (HMD) had abnormal surface properties' prompted a number of attempts to treat the condition by administration of material with surface tension-lowering properties. The substance mainly used for this purpose during the period 1964-7 was synthetic dipalmitoyllecithin (DPL) prepared as an aerosol either in a mixture...
متن کاملArtificial surfactant therapy in hyaline-membrane disease.
Ten preterm infants severely ill with hyaline-membrane disease (HMD) were given artificial surfactant endotracheally. Oxygenation and alveolar-arterial oxygen gradients improved, the levels of inspired oxygen and peak respirator pressure could be reduced, and many of the radiological abnormalities resolved. Acidosis and systemic hypotension were also reversed. In nine infants a patent ductus ar...
متن کاملRandomized controlled trial of exogenous surfactant for the treatment of hyaline membrane disease.
We conducted a prospective, randomized, unblinded, controlled trial of exogenous bovine surfactant (surfactant TA) in premature infants requiring ventilator support for the treatment of severe hyaline membrane disease. Forty-one low birth weight infants with severe hyaline membrane disease were randomly assigned to saline or surfactant therapy and treated within eight hours of birth. Significan...
متن کاملPrevention of Hyaline Membrane Disease
The high mortality of respiratory distress syndrome in premature infants and the relative ineffectiveness of treatment' make two recent reports of special interest. They are clinical studies2 3 which attempt to clarify the role of corticosteroids in prevention and treatment. New forms of treatment for this puzzling disorder have sometimes been introduced without adequate trials, so that it is h...
متن کاملHyaline membrane disease. II. Lung lecithin.
Boughton, K., Gandy, G., and Gairdner, D. (1970). Archives of Disease in Childhood, 45, 311. Hyaline membrane disease. H: Lung lecithin. The lecithin content of lung, together with its surface tension properties, were determined in 34 stillbirths, and 61 neonatal deaths. Lecithin content ranged widely from 1-5 to 18 6% of dry lung tissue. In 24 cases the 'palmitic-lecithin' was also measured; i...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1980
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.55.10.753