Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable?
نویسندگان
چکیده
منابع مشابه
Articular Cartilage Repair
This review traces the genealogy of the field of articular cartilage repair from its earliest attempts to its present day vast proliferation of research advances. Prior to the 1980s there was only sporadic efforts to regenerate articular cartilage as it was considered to be incapable of regeneration based on historical dogma. The first flurry of reports documented the use of various cell types ...
متن کاملIntrinsic repair of full-thickness articular cartilage defects in the axolotl salamander.
OBJECTIVE The ability to fully regenerate lost limbs has made the axolotl salamander (Ambystoma mexicanum) a valuable model for studies of tissue regeneration. The current experiments investigate the ability of these vertebrates to repair large articular cartilage defects and restore normal hyaline cartilage and joint structure independent of limb amputation. METHODS Full-thickness articular ...
متن کاملArticular Cartilage: Structure, Composition, Injuries and Repair
Articular cartilage has a unique structure that makes it very different from any other tissues in the body. It has such specific roles and functions such as weight bearing with low frictional coefficient that the main bulk of its structure is based on that alone, thus making it a vascular, and thereby greatly limiting its self regeneration capabilities. This article aims to review the structure...
متن کاملCurrent strategies for articular cartilage repair.
Defects of articular cartilage that do not penetrate to the subchondral bone fail to heal spontaneously. Defects that penetrate to the subchondral bone elicit an intrinsic repair response that yields a fibrocartilaginous repair tissue which is a poor substitute for hyaline articular cartilage. Many arthroscopic repair strategies employed utilise this intrinsic repair response to induce the form...
متن کاملMRI Assessment of Articular Cartilage Repair
Articular cartilage lesions in the young population predispose to the development of precocious osteoarthritis. Poor healing of cartilage damaged by trauma or degeneration has been ascribed to avascularity. Cartilage lesions are associated with significant morbidity, including lifestyle restrictions, especially in individuals engaged in sports. The past decade has seen the evolution of a number...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 1999
ISSN: 1063-4584
DOI: 10.1053/joca.1998.0159