Arsenic Toxicity in Male Reproduction and Development
نویسندگان
چکیده
منابع مشابه
Arsenic Toxicity in Male Reproduction and Development
Arsenic is a toxic metalloid that exists ubiquitously in the environment, and affects global health problems due to its carcinogenicity. In most populations, the main source of arsenic exposure is the drinking water. In drinking water, chronic exposure to arsenic is associated with increased risks of various cancers including those of skin, lung, bladder, and liver, as well as numerous other no...
متن کاملDetection of Toxicity to Reproduction for Medicinal Products including Toxicity to Male Fertility *)
Guideline Title Detection of Toxicity to Reproduction for Medicinal Products Including Toxicity to Male Fertility *) Legislative basis Directive 75/318/EEC as amended Date of first adoption First adopted October 1983 This version incorporates version adopted September 1993 and addendum on male fertility adopted 1995. Date of entry into force June 1996 Status Last revised 1995 (male fertility) P...
متن کاملAssessing Male Reproductive Toxicity during Drug Development
Male infertility accounts for about 50% of infertility cases [1]. Anatomic, genetic, endocrinological, environmental, behavioral and nutritional imbalances are critical causes of male infertility [2-5]. Therapeutic drugs can also adversely affect male fertility by injuring testicular cells or instigate hormonal changes that lead to decreased semen quality (Figure 1) thereby compromising the pro...
متن کاملAcute and chronic arsenic toxicity.
Arsenic toxicity is a global health problem affecting many millions of people. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Arsenic is present as a contaminant in many traditional remedies. Arsenic trioxide is now used to treat acute promyelocytic leukaemia. ...
متن کاملMultigeneration Reproduction and Male Developmental Toxicity Studies on Atrazine in Rats
BACKGROUND Reproductive toxicity of Atrazine (ATR) was evaluated in two rat multigenerational studies. Development of male reproductive parameters was evaluated in separate studies after prenatal or postnatal exposure. METHODS In multigenerational studies, rats received dietary concentrations of 0, 10, 50, 100 or 500 ppm ATR. In separate studies in female rats, ATR was administered by gavage ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Development & Reproduction
سال: 2015
ISSN: 2465-9525,2465-9541
DOI: 10.12717/dr.2015.19.4.167