Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study.
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چکیده
منابع مشابه
Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study.
The present study was designed to establish the form of the dose-response relationship for dietary sodium arsenite as a co-carcinogen with ultraviolet radiation (UVR) in a mouse skin model. Hairless mice (strain Skh1) were fed sodium arsenite continuously in drinking water starting at 21 days of age at concentrations of 0.0, 1.25, 2.5, 5.0, and 10 mg/L. At 42 days of age, solar spectrum UVR exp...
متن کاملArsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis.
Although epidemiological evidence shows an association between arsenic in drinking water and increased risk of skin, lung, and bladder cancers, arsenic compounds are not animal carcinogens. The lack of animal models has hindered mechanistic studies of arsenic carcinogenesis. Previously, this laboratory found that low concentrations of arsenite (the likely environmental carcinogen) which are not...
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A new method for autoradiographic measurement of unscheduled DNA synthesis (UDS) in the skin in vivo after treatment with ultraviolet light (UV) was developed. The skin of the back of ICR mice was shaved and exposed to short-wave UV (254 nm) or UVAB (sunlamp, 270 to 440 nm, predominant emission at 312 nm) at various doses. Immediately after irradiation, an isotonic aqueous solution of [methyl-3...
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The use of chemical and physical sunscreening agents has increased dramatically during the last two to three decades as an effective means of preventing sunbum. The use of high sunprotection factor sunscreens has also been widely promoted for the prevention of skin cancer, including melanoma. Whereas sunscreens are undoubtedly effective in preventing sunbum, their efficacy in preventing skin ca...
متن کاملUltraviolet Radiation and the Skin Immune Response
ULTRAVIOLET RADIATION AND THE SKIN IMMUNE RESPONSE Ivana Nola, Kreimir Kostoviæ, Lena Kotrulja, Liborija Lugoviæ, Jelena Metroviæ-tefekov and Ines Sjerobabski-Masnec University Department of Dermatovenerology, Sestre milosrdnice University Hospital, Zagreb, Croatia SUMMARY At present, ultraviolet radiation (UVR) represents one of the most important environmental factors affecting mankind. ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2004
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.6655