Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation
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چکیده
منابع مشابه
Bi-directional coupling between dihydropyridine receptors and ryanodine receptors.
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We demonstrate that a shift of the vulnerable window caused by tissue inhomogeneity can play a role in the generation of reentrant excitation. The Earm-Hilgemann-Noble equations were incorporated into 1and 2-dimensional inhomogeneous partial di erential equation models of atrial tissue. Inhomogeneity was produced by a reduction of gNa over part of the medium and the vulnerable window for initia...
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gitudinal system of the SR, governing the Ca storage compartment with the highest recruitable amount of Ca in cardiac myocytes. The RyR are chemically coupled to L-type Ca channels via Ca, and a relatively small amount of Ca entering the cell via L-type Ca channels (depending on species or stimulation rate) activates a limited number of adjacent RyRs. This leads to Ca release from the SR, and a...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2019
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1007260