Aromatase Cytochrome P450 and Extragonadal Estrogen Play a Role in Ischemic Neuroprotection
نویسندگان
چکیده
منابع مشابه
Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection.
Female animals are protected from many forms of neurological injury and degeneration relative to their male counterparts, in part attributable to their native estrogens. We hypothesized that estradiol aromatized from precursor androgens via the cytochrome P450 aromatase contributes to ischemic neuroprotection in the female. Female homozygous aromatase knock-out (ArKO) mice and randomly cycling,...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2003
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.23-25-08701.2003