Aristophanes, <i>Ecclesiazusae</i> 923

Npgrj_NN_1927 923..929

In mammals, identifying the contribution of specific neurons or networks to behavior is a key challenge. Here we describe an approach that facilitates this process by enabling the rapid modulation of synaptic inhibition in defined cell populations. Binding of zolpidem, a systemically active allosteric modulator that enhances the function of the GABAA receptor, requires a phenylalanine residue (...

Aristophanes on Tragedy

Fifty years before Aristotle wrote his Poetics, Aristophanes had devoted two comedies, Thesmophoriazusae (411) and Frogs (405), to the subject of tragedy. In both plays the plot shows the education of the main character in the nature of tragedy. Euripides learns in Thesmophoriazusae that he must present noble and not base women in his dramas. His depiction of perverse women in the theatre had m...

The Ionian at Aristophanes

Dmd050344 923..931

The subarachnoid space, where cerebrospinal fluid (CSF) flows over the brain and spinal cord, is lined on one side by arachnoid barrier (AB) cells that form part of the blood-CSF barrier. However, despite the fact that drugs are administered into the CSF and CSF drug concentrations are used as a surrogate for brain drug concentration following systemic drug administration, the tightjunctioned A...

C2sm06685h 923..926

We describe the creation of monodisperse microbeads of polydimethylsiloxane (PDMS) via a microfluidic approach. Using a flow-focusing configuration, a PDMS precursor solution is dispersed into microdroplets within an aqueous continuous phase. These droplets are collected and thermally cured off-chip into solid microbeads. Our microfluidic technique allows for direct integration of payloads into...