Argininosuccinate Synthetase Activity in Parotid Glands
نویسندگان
چکیده
منابع مشابه
Nitro analogs of substrates for argininosuccinate synthetase and argininosuccinate lyase.
The nitro analogs of aspartate and argininosuccinate were synthesized and tested as substrates and inhibitors of argininosuccinate synthetase and argininosuccinate lyase, respectively. The Vmax for 3-nitro-2-aminopropionic acid was found to be 60% of the maximal rate of aspartate utilization in the reaction catalyzed by argininosuccinate synthetase. Only the nitronate form of this substrate, in...
متن کاملMolecular definition of bovine argininosuccinate synthetase deficiency.
Citrullinemia is an inborn error of metabolism due to deficiency of the urea cycle enzyme, argininosuccinate synthetase [L-citrulline:L-aspartate ligase (AMP-forming), EC 6.3.4.5]. The disease was first described in humans but was recently reported in dairy cattle in Australia. Here we report the nucleotide sequence of the normal bovine cDNA for argininosuccinate synthetase and the mutation pre...
متن کاملMolecular analysis of argininosuccinate synthetase deficiency in human fibroblasts.
We have analyzed cultured skin fibroblasts derived from patients with argininosuccinate synthetase deficiency for alterations in gene structure, mRNA content, and protein structure. Genomic DNA was digested with the endonucleases EcoRI or HindIII, and the fragments were analyzed by Southern blotting and hybridization with a cDNA probe for argininosuccinate synthetase. The blot pattern is comple...
متن کاملArgininosuccinate synthetase activity and citrulline metabolism in cells cultured from a citrullinemic subject.
Citrullinemia-is one of several human diseases caused by a defect in the KrebsHenseleit urea cycle. In this disorder a deficiency of liver argininosuccinate synthetase has been reported.' 1\Iorrow and his colleagues have recently described an infant with this condition2 and a fibroblast-like cell line has been derived from a skin biopsy of this child. In studying minimal media requirements for ...
متن کاملFat deposition of parotid glands.
UNLABELLED Parotid gland parenchyma histology may be altered by local or systemic, pathological or nonpathological conditions. OBJECTIVE This paper aims to highlight the fatty degeneration of the parotid gland, a not well-known non-pathological condition. METHOD In a retrospective study, we collected a series of 6 patients which presented a swelling of the parotid, but even after extensive ...
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ژورنال
عنوان ژورنال: International Journal of Oral-Medical Sciences
سال: 2005
ISSN: 1347-9733,2185-4254
DOI: 10.5466/ijoms.4.47