Arel-glutamate and ATP cotransmitters of the peripheral chemoreflex in the rat nucleus tractus solitarius?
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چکیده
منابع مشابه
Glutamate receptors in the nucleus tractus solitarius contribute to ventilatory acclimatization to hypoxia in rat.
When exposed to a hypoxic environment the body's first response is a reflex increase in ventilation, termed the hypoxic ventilatory response (HVR). With chronic sustained hypoxia (CSH), such as during acclimatization to high altitude, an additional time-dependent increase in ventilation occurs, which increases the HVR. This secondary increase persists after exposure to CSH and involves plastici...
متن کامل[Effects of protein tyrosine kinase within the brainstem nucleus tractus solitarius on the ventilatory responses of peripheral chemoreflex].
The aim of the present study was to observe whether protein tyrosine kinase (PTK) within the nucleus tractus solitarius (NTS) was involved in the regulation of ventilatory responses of peripheral chemoreflex. The experiments were performed on anesthetized, immobilized and artificially ventilated rabbits. Peripheral chemoreflex was elicited by ventilating the animal with 10% O2-balance 90% N2. C...
متن کاملExtracellular ATP both inhibits and facilitates calcium channel currents in acutely dissociated rat nucleus tractus solitarius.
The postsynaptic actions of exogenously applied adenosine 5'-triphosphate (ATP) were investigated in nucleus tractus solitarius (NTS) of the rat. Whole cell patch-clamp recordings were used to examine the regulation of voltage-dependent Ca2+ channels (VDCCs) currents (I(Ca)) by ATP in freshly dissociated NTS. Application of ATP inhibited I(Ca) from -905 pA to -741 pA. In addition to this inhibi...
متن کاملThe effect of nucleus tractus solitarius inactivation on blood pressure in diabetic rats
The role of nucleus tractus solitarius (NTS) in cardiovascular system regulation is controversial. On the other hand, the problem of hypertension in diabetic animals is the subject of many research programs. The aim of present study was to determine whether inactivation of NTS could affect blood pressure and heart rate in diabetic rats. To this end, stereptozotocin induced diabetic rats were an...
متن کاملThe effect of nucleus tractus solitarius inactivation on blood pressure in diabetic rats
The role of nucleus tractus solitarius (NTS) in cardiovascular system regulation is controversial. On the other hand, the problem of hypertension in diabetic animals is the subject of many research programs. The aim of present study was to determine whether inactivation of NTS could affect blood pressure and heart rate in diabetic rats. To this end, stereptozotocin induced diabetic rats were an...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 2008
ISSN: 0958-0670
DOI: 10.1113/expphysiol.2008.043653