منابع مشابه
PERSPECTIVES Are rate constants constant?
2006;571;502-; originally published online Feb 2, 2006; J. Physiol. Stephen W. Jones Are rate constants constant? This information is current as of March 21, 2006 publication unless article is open access. This version of the article may not be posted on a public website for 12 months after http://jp.physoc.org/cgi/content/full/571/3/502 This is the final published version of this article; it i...
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MOTIVATION Scale-free networks have had a profound impact in Biology. Network theory is now used routinely to visualize, navigate through, and help understand gene networks, protein-protein interactions, regulatory networks and metabolic pathways. Here we analyse the numerical rather than topological properties of biological networks and focus on the study of kinetic rate constants within pathw...
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Evolutionary conservation of protein interaction properties has been shown to be a valuable indication for functional importance. Here we use homology interface modeling of 10 Ras-effector complexes by selecting ortholog proteins from 12 organisms representing the major eukaryotic branches, except plants. We find that with increasing divergence time the sequence similarity decreases with respec...
متن کاملEstimating rate constants in
The EM algorithm, e.g. as Baum-Welch reestimation, is an important tool for parameter estimation in discrete-time Hidden Markov Models. We present a direct reestimation of rate constants for applications in which the underlying Markov process is continuous in time. Previous estimation of discrete-time transition probabilities is not necessary.
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2006
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2006.106476