Are mannose-binding lectin gene 2 (MBL2) polymorphisms and MBL deficiency associated with infections?
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چکیده
منابع مشابه
Mannose-binding lectin gene polymorphisms are associated with major
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متن کاملMannose-binding lectin 2 (MBL2) gene polymorphisms do not influence frequency of infections in chronic lymphocytic leukemia patients
BACKGROUND Infectious complications represent the main cause of morbidity and mortality in chronic lymphocytic leukemia. It has been reported that polymorphisms of the mannosebinding lectin 2 (MBL2) genes are correlated with MBL protein serum levels and, consequently, are associated with the development of infectious diseases. OBJECTIVE The purpose of this study was to investigate the possibl...
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One of the important parts of innate immunity is complement system that occurs in three different ways; the classic, the alternative and the lectin pathway. The four pattern recognition molecules that have been identified till now are Mannose binding lectin (MBL), a component of lectin pathway, and three ficolins (ficolin1,-2 and -3) which compound to the carbohydrates of the cell surface. MBL ...
متن کاملMannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation.
Life-threatening complications such as graft versus host disease and infection remain major barriers to the success of allogeneic hemopoietic stem cell transplantation (SCT). While pretransplantation conditioning and posttransplantation immunosuppression are important risk factors for infection, the reasons that similarly immunosuppressed transplant recipients show marked variation in frequency...
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ژورنال
عنوان ژورنال: Indian Journal of Human Genetics
سال: 2011
ISSN: 0971-6866
DOI: 10.4103/0971-6866.86170