Archaic hominin introgression into modern human genomes
نویسندگان
چکیده
منابع مشابه
Analysis of Human Accelerated DNA Regions Using Archaic Hominin Genomes
Several previous comparisons of the human genome with other primate and vertebrate genomes identified genomic regions that are highly conserved in vertebrate evolution but fast-evolving on the human lineage. These human accelerated regions (HARs) may be regions of past adaptive evolution in humans. Alternatively, they may be the result of non-adaptive processes, such as biased gene conversion. ...
متن کاملDynamics of Adaptive Introgression from Archaic to Modern Humans
Recent evidence from the genomic variation of living people documents genetic contributions from archaic to later modern humans. This evidence of introgression contrasts with earlier findings from single loci that appeared to exclude archaic human genetic survival. The present evidence indicates that many “archaic” alleles may represent relicts of African archaics, and that some “archaic” varia...
متن کاملThe Evolution and Functional Impact of Human Deletion Variants Shared with Archaic Hominin Genomes
Allele sharing between modern and archaic hominin genomes has been variously interpreted to have originated from ancestral genetic structure or through non-African introgression from archaic hominins. However, evolution of polymorphic human deletions that are shared with archaic hominin genomes has yet to be studied. We identified 427 polymorphic human deletions that are shared with archaic hom...
متن کاملArchaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation
One of the most abundant proteins in human saliva, mucin-7, is encoded by the MUC7 gene, which harbors copy number variable subexonic repeats (PTS-repeats) that affect the size and glycosylation potential of this protein. We recently documented the adaptive evolution of MUC7 subexonic copy number variation among primates. Yet, the evolution of MUC7 genetic variation in humans remained unexplore...
متن کاملSignatures of Archaic Adaptive Introgression in Present-Day Human Populations
Comparisons of DNA from archaic and modern humans show that these groups interbred, and in some cases received an evolutionary advantage from doing so. This process-adaptive introgression-may lead to a faster rate of adaptation than is predicted from models with mutation and selection alone. Within the last couple of years, a series of studies have identified regions of the genome that are like...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Physical Anthropology
سال: 2019
ISSN: 0002-9483,1096-8644
DOI: 10.1002/ajpa.23951