Arbutus unedo: Innovative Source of Antioxidant, Anti-Inflammatory and Anti-Tyrosinase Phenolics for Novel Cosmeceuticals

Phenolic compounds are valuable cosmetic ingredients. They display skin protective potential and play an important role in preserving formulations due to their ability neutralize free radicals. Considering this fact, the current study aims obtain a phenolic-enriched fraction from Arbutus unedo for topical application cosmeceutical products. The chemical composition antioxidant, anti-inflammatory, anti-tyrosinase activities of different extracts plant were investigated compared. Samples obtained by maceration, reflux, ultrasound using water ethanol. findings indicated that extraction methods impacted phytochemical extracts. high-performance liquid chromatography with diode-array detection (HPLC–DAD) analysis showed wide range phenolic compounds, comprising acids flavonoids. Among extracts, reflux had significant levels both total polyphenols, flavonoids, tannins possessed most content on hyperoside. It displayed antioxidant high antiradical reducing power, as well strong activity. possesses promising whitening effect activities. Furthermore, it shows no cytotoxicity moderate anti-inflammatory Finally, its yield efficiency activities, was selected formulate oil-in-water nanoemulsion optimal pH stability.