AR Suppresses Transcription of the LHβ Subunit by Interacting with Steroidogenic Factor-1
نویسندگان
چکیده
منابع مشابه
AR suppresses transcription of the LHbeta subunit by interacting with steroidogenic factor-1.
Synthesis of LH is suppressed by feedback from gonadal steroids. Previously, we demonstrated that 779 bp of the bovine LHbeta promoter was sufficient to target expression of a chloramphenicol acetyltransferase reporter gene specifically to the pituitary in transgenic mice, and found that it was appropriately suppressed after administration of T or E2. In this study, we report that ligand-bound ...
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15 صفحه اولExpression of Steroidogenic Factor 1 and Pituitary Specific Transcription Factor 1 in Rat Pituitary Adenomas
The protein expressions of steroidogenic factor l (SF-l) and pituitary-specific transcription factor 1 (Pit-1) were investigated immunohistochemically for 53 spontaneous pituitary adenomas of the pars distalis from male Crl:CD(SD) rats. Luteinizing hormone (LH)-positive/prolactin (PRL)-negative and LH-negative/PRL-positive adenomas showed that the expression of SF-1 and Pit-1 was exclusively re...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2001
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.15.9.0691