Aqueous Oxidative Heck Reaction as a Protein-Labeling Strategy
نویسندگان
چکیده
منابع مشابه
Aqueous Oxidative Heck Reaction as a Protein-Labeling Strategy
An increasing number of chemical reactions are being employed for bio-orthogonal ligation of detection labels to protein-bound functional groups. Several of these strategies, however, are limited in their application to pure proteins and are ineffective in complex biological samples such as cell lysates. Here we present the palladium-catalyzed oxidative Heck reaction as a new and robust bio-ort...
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The rate of the Pd/C catalyzed Heck coupling of Ar-I with CH(2)=CH-R is accelerated tenfold by the presence of Aliquat 336 (A336), a well known phase transfer catalyst, and an ionic liquid. Both when conducted in A336 as solvent, and in an isooctane/A336/aqueous triphasic mixture, the Heck reaction of aryl iodides with electron deficient olefins, catalyzed by Pd/C, proceeds with high yields and...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2013
ISSN: 1439-4227
DOI: 10.1002/cbic.201300714