Aquaporins: Their role in cholestatic liver disease
نویسندگان
چکیده
منابع مشابه
Cholestatic liver disease in children.
Inherited syndromes of intrahepatic cholestasis and biliary atresia are the most common causes of chronic liver disease and the prime indication for liver transplantation in children. Our understanding of the pathogenesis of these diseases has increased substantially by the discovery of genetic mutations in children with intrahepatic cholestasis and the findings that inflammatory circuits are o...
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Cholestatic liver disease (CLD) in children negatively affects nutritional status, growth and development, which all lead to an increased risk of morbidity and mortality. This is illustrated by the fact that the clinical outcome of children with CLD awaiting a liver transplantation is in part predicted by their nutritional status, which is integrated in the pediatric end-stage liver disease mod...
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Cholestatic liver diseases are conditions with impaired bile formation and/or flow due to genetic, immunologic, environmental, or other causes. Unless successfully treated, this can lead to chronic liver injury and end-stage liver disease. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) embody the most prominent adult cholestatic liver diseases with regard to incidenc...
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Cutaneous polyarteriitis nodosa (CPAN) is a rare relapsing disease in childhood. Associations with other autoimmune diseases have been described in some patients. The etiologic role of Streptococcal infection, HCV, HBV and other triggers has been widely discussed in the past with no conclusive data about their exact mechanism of action and clinical significance. We present the 10-year follow-up...
متن کاملThe role of mitochondria in cholestatic liver injury.
There is increasing evidence that the integrity of antioxidant defenses is of vital importance in extrahepatic cholestasis, particularly with regard to the functioning of the liver's mitochondria. Although the mechanisms by which cholestasis causes oxidant/antioxidant imbalance in mitochondria are poorly understood, hepatic injury caused by cholestasis may be due to oxidative stress from the mi...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2008
ISSN: 1007-9327
DOI: 10.3748/wjg.14.7059