Aquaporin-1 and Aquaporin-3 Expressions in the Intervertebral Disc of Rats with Aging
نویسندگان
چکیده
منابع مشابه
Aquaporin 3 protects against lumbar intervertebral disc degeneration via the Wnt/β-catenin pathway.
Previous studies have demonstrated that the expression of aquaporin 3 (AQP3), a water channel which promotes glycerol permeability and water transport across cell membranes, is reduced in degenerative lumbar intervertebral disc (IVD) tissues. However, the role of AQP3 in the pathogenesis of IVD degeneration has not recieved much scholarly attention. The objective of the present study was to inv...
متن کاملAquaporin-1 Expression in Herniated Human Lumbar Intervertebral Discs
STUDY DESIGN Case series. OBJECTIVE Intervertebral disc (IVD) degeneration is the cause of spondylosis. The pathogenesis is poorly understood, but disc dehydration often plays a role. In this study, we aim to identify and quantify aquaporin-1 (AQP1) in ex vivo human degenerated IVDs obtained intraoperatively and to investigate the relationship between AQP1 levels and magnetic resonance imagin...
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Increasing evidence suggests that the water/glycerol channel aquaporin-3 (AQP3) plays a pivotal role in cancer metastasis. AQP3 knockout mice were resistant to skin tumor formation and overexpression correlated with metastasis and poor prognosis in patients with breast or gastric cancer. In cultured cancer cells, increased AQP3 expression stimulated several intracellular signaling pathways and ...
متن کاملInvestigation of the effects of aging on the expression of aquaporin 1 and aquaporin 4 protein in heart tissue
OBJECTIVE Aquaporin (AQP) 1 and AQP 4 are expressed in human heart and several studies have been focused on these two aquaporins. For this purpose, the present study is aimed to research the effects of aging on AQP 1 and AQP 4 in heart tissue. METHODS In this study, 14 Balb/C type white mice were used. Animals were divided into two equal groups. Group I consisted of 2-month-old young animals ...
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ژورنال
عنوان ژورنال: Balkan Medical Journal
سال: 2012
ISSN: 2146-3123,2146-3131
DOI: 10.5152/balkanmedj.2012.079