منابع مشابه
Aprotinin in orthotopic liver transplantation.
Aprotinin is a protease inhibitor isolated from bovine lungs and othcr lissues. Its biochcmical struc!Urc, a single-chain polypeptide of 6.5 12 kD , and biophysical properties are weH defined. I The activity of commcrcial preparations of apralini n is usually describcd in kallikrein inac ti valor unils (KIU) , 0. 1 million KIU being equivalent 102. 15 j-Lmol of apralinin per liter. Sy inhibitin...
متن کاملBlood conservation in liver transplantation: The role of aprotinin.
ORTHOTOPIC LIVER transplantation has become an accepted treatment for end-stage chronic liver disease, with patient survival rates of 80% to 90%.1 In addition, it can be a life-saving procedure in patients with fulminant hepatic failure and an effective treatment for several metabolic disorders. Currently, a total of about 10,000 liver transplantations are performed each year in the United Stat...
متن کاملReduced need for vasopressors in patients receiving aprotinin during orthotopic liver transplantation.
BACKGROUND Graft reperfusion in orthotopic liver transplantation is often associated with significant hemodynamic changes, including decreased systemic vascular resistance and arterial blood pressure. Vasopressive drugs are often required to maintain adequate perfusion pressure during the early postreperfusion period. The exact mechanism of this postreperfusion syndrome is unknown, but release ...
متن کاملImproved haemodynamic stability with administration of aprotinin during orthotopic liver transplantation.
In a placebo-controlled, double-blind study, we have investigated the hypothesis that patients for orthotopic liver transplantation (OLT) treated with high-dose aprotinin (serum concentrations > or = 200 kiu ml-1) show greater haemodynamic stability on graft reperfusion. We studied 55 adult patients presenting for OLT, and 52 were included in the analysis. The treatment and placebo groups were ...
متن کاملFecal Microbiota Transplantation in Liver Diseases and Recent Developments
Introduction: The intestine, as an important part of the human gastrointestinal tract, provides a favorable milieu for the growth and development of a diverse and large population (approximately 1000 species) of bacteria. Currently, the presence of a cohesive relationship between intestinal bacteria and the host is being well studied and identified. According to the available scientific evidenc...
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ژورنال
عنوان ژورنال: Hepatology
سال: 1998
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.510270439