Applied Proteomics

Redox Proteomics Applied to the Thiol Secretome.

SIGNIFICANCE Secreted proteins are important both as signaling molecules and potential biomarkers. Recent Advances: Protein can undergo different types of oxidation, both in physiological conditions or under oxidative stress. Several redox proteomics techniques have been successfully applied to the identification of glutathionylated proteins, an oxidative post-translational modification consist...

Transcriptomics and Proteomics Applied to Developmental Toxicology

Chemical proteomics applied to target identification and drug discovery.

Introduction In the past decade, DNA sequencing of multiple organisms has provided us with our first look at complete lists of protein products expressed from a whole genome. The field of proteomics is now challenged with the task of elucidating the cellular functions of these proteins in both normal and pathological processes (1–3). Several proteomic techniques, such as 2-dimensional gel-elect...

Pharmaceutical Advances and Proteomics Researches

Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...

Cardiovascular Proteomics: Evolution and Potential Proteomics in the Cardiomyopathies and Heart Failure: A Step Beyond Genomics Dynamic Cellular Response: Detection and Characterization of Protein Posttranslational Modification Applied Proteomics: Receptor-Mediated Response Applied Proteomics: Mitochondrial Proteins and Effect on Function

The development of proteomics is a timely one for cardiovascular research. Analyses at the organ, subcellular, and molecular levels have revealed dynamic, complex, and subtle intracellular processes associated with heart and vascular disease. The power and flexibility of proteomic analyses, which facilitate protein separation, identification, and characterization, should hasten our understandin...