Applications of Multiple Reaction Monitoring to Clinical Glycomics

Optical Elastography: From Theory to Clinical Applications

O22: Report of the Milan Consensus Conference About Clinical Applications of Intracranial Pressure Monitoring in Traumatic Brain Injury

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N-acetylcysteine: multiple clinical applications.

N-acetylcysteine is the acetylated variant of the amino acid L-cysteine and is widely used as the specific antidote for acetaminophen overdose. Other applications for N-acetylcysteine supplementation supported by scientific evidence include prevention of chronic obstructive pulmonary disease exacerbation, prevention of contrast-induced kidney damage during imaging procedures, attenuation of ill...

Label-Free Absolute Quantitation of Oligosaccharides Using Multiple Reaction Monitoring

An absolute quantitation method for measuring free human milk oligosaccharides (HMOs) in milk samples was developed using multiple reaction monitoring (MRM). To obtain the best sensitivity, the instrument conditions were optimized to reduce the source and postsource fragmentation prior to the quadrupole transmission. Fragmentation spectra of HMOs using collision-induced dissociation were studie...

Some extensions and applications of a Bayesian strategy for monitoring multiple outcomes in clinical trials.

We present some practical extensions and applications of a strategy proposed by Thall, Simon and Estey for designing and monitoring single-arm clinical trials with multiple outcomes. We show by application how the strategy may be applied to construct designs for phase IIA activity trials and phase II equivalence trials. We also show how it may be extended to incorporate the use of mixture prior...