Applications of Cell-Free Fetal DNA in Maternal Serum
نویسندگان
چکیده
منابع مشابه
Applications of Cell-Free Fetal DNA in Maternal Serum
Cell-free fetal DNA (cffDNA) is available in the maternal circulation throughout pregnancy and can be used for noninvasive prenatal diagnosis including, determination of fetal sex, identification of specific single gene disorders, typing of fetal blood groups (RhD), paternity determination and potentially routine use for Down’s syndrome (DS) testing of all pregnancies. I searched published lite...
متن کاملCell-free fetal DNA in the maternal serum and plasma: current and evolving applications.
PURPOSE OF REVIEW Free fetal nucleic acids, found in the plasma of every pregnant woman, have made a substantial impact on prenatal diagnosis. The past decade has seen the introduction of routine noninvasive prenatal diagnosis (NIPD) using DNA extracted from maternal plasma for a number of clinical complications of pregnancy, notably feto-maternal blood group incompatibility, fetal sexing and e...
متن کاملevaluation of a modified dna extraction method for isolation of cell-free fetal dna from maternal serum
background: discovery of short cell free fetal dna (cffdna) fragments in maternal plasma has created major changes in the field of prenatal diagnosis. the use of cffdna to set up noninvasive prenatal test is limited due to the low concentration of fetal dna in maternal plasma therefore, employing a high efficiency extraction method leads to more accurate results. the aim of this study was to ev...
متن کاملUtility of Maternal Serum Analyte Screening in the Era of Cell-free Fetal DNA
Background: To determine whether in the era of cell-free fetal DNA (cffDNA), first and second trimester maternal serum analytes will be obsolete or whether they have a role in predicting adverse pregnancy outcomes. Methods: Retrospective cohort study using maternal serum analyte results from first trimester and sequential screening tests from 1/2002 to 12/2012. Abnormal serum analytes included ...
متن کاملnoninvasive prenatal test by cell-free fetal dna in maternal plasma: current progress and prospective clinical applications
context prenatal testing aims to identify fetal chromosomal and genetic disorders prior to delivery. current invasive procedures such as amniocentesis and chorionic villus sampling (cvs) pose a risk to mother and fetus and such diagnostic procedures are available only to high-risk pregnancies, which limits aneuploidy detection rate. the identification of cell-free fetal dna (cffdna) in maternal ...
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ژورنال
عنوان ژورنال: International Journal of Infertility & Fetal Medicine
سال: 2012
ISSN: 2229-3817,2229-3833
DOI: 10.5005/jp-journals-10016-1038