Applications of 211At and 223Ra in Targeted Alpha-Particle Radiotherapy
نویسندگان
چکیده
منابع مشابه
211At-methylene blue in targeted radiotherapy of disseminated melanoma.
Targeted radiotherapy with 211At-methylene blue (211At-MTB) is a systemic treatment selectively directed at melanoma due to a high affinity of MTB to melanin synthesized in the tumor cells. Since MTB forms a strong complex with melanin, it is an effective carrier for a number of radioisotopes to be addressed to the tumor deposits of any size including individually dispersed melanoma cells. Thus...
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متن کاملsystemic targeted alpha radiotherapy for cancer
background: the fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.the high linear energy transfer (let) of alpha radiation to the targeted cancer cellscauses double strand breaks in dna. at the same time, the short range radiation spares adjacent normal tissues. this targeted approach complements conventional external beam radiotherapy and ch...
متن کاملSystemic Targeted Alpha Radiotherapy for Cancer
BACKGROUND The fundamental principles of internal targeted alpha therapy forcancer were established many decades ago.The high linear energy transfer (LET) ofalpha radiation to the targeted cancer cellscauses double strand breaks in DNA. Atthe same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and chemot...
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Glioblastoma (GBM) is the most aggressive primary malignant brain cancer that invariably results in a dismal prognosis. Chemotherapy and radiotherapy have not been completely effective as standard treatment options for patients due to recurrent disease. We and others have therefore developed molecular strategies to specifically target interleukin 13 receptor alpha 2 (IL13RA2), a GBM restricted ...
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ژورنال
عنوان ژورنال: Current Radiopharmaceuticalse
سال: 2011
ISSN: 1874-4710
DOI: 10.2174/1874471011104040283