Application of the solid dispersion method to controlled release of medicine. I. Controlled release of water soluble medicine by using solid dispersion.
نویسندگان
چکیده
منابع مشابه
development and characterization of controlled release polar lipid microparticles of candesartan cilexetil by solid dispersion
candesartan cilexetil (cc) is a newer class of angiotensin ii receptor antagonist used for the treatment of hypertension. the solubility of the cc is very poor and its oral bioavailability is only 15%. the controlled-release polar lipid microparticles of cc (formulations f1, f2, f3 and f4) were prepared using variable erodible lipophilic excipients like hydrogenated castor oil, stearic acid, ce...
متن کاملDevelopment and characterization of controlled release polar lipid microparticles of candesartan cilexetil by solid dispersion
Candesartan cilexetil (CC) is a newer class of angiotensin II receptor antagonist used for the treatment of hypertension. The solubility of the CC is very poor and its oral bioavailability is only 15%. The controlledrelease polar lipid microparticles of CC (formulations F1, F2, F3 and F4) were prepared using variable erodible lipophilic excipients like hydrogenated castor oil, stearic acid, cet...
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Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, e...
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Epigallocatechin gallate (EGCG) has been recognized as the most prominent green tea extract due to its healthy influences. The high instability and low bioavailability, however, strongly limit its utilization in food and drug industries. This work, for the first time, develops amorphous solid dispersion of EGCG to enhance its bioavailability and physical stability. Four commonly used polymeric ...
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abstract this study evaluated and compared medical terminology and english for the students of medicine (ii) as two representatives of the textbooks available on the iranian market for teaching english to the students of medicine. this research was performed on the basis of a teacher’s and a number of students’ attitudes and the students’ needs analysis for two reasons: first, to investigate...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1991
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.39.465