Application of sustained release microsphere in hypoparathyroidism after thyroid surgery
نویسندگان
چکیده
منابع مشابه
Iatrogenic hypoparathyroidism – not only after thyroid surgery ...
The most common causes of hypoparathyroidism are iatrogenic: mostly thyroid or parathyroid surgery. Much less frequently HypoPT is caused by an extensive oncological surgical procedure e.g. because of larynx or upper throat cancer, or external neck radiotherapy, e.g. in the case of lymphoma. In those particular cases, both patients and doctors focus their attention on the oncological nature of ...
متن کاملHypoparathyroidism--presenting 40 years after thyroid surgery.
Serum calcium was 1.25 mmol/L (normal range 2.10-2.60 mmol/L); phosphate 1.97 mmol/L (normal range 0.8-1.55 mmol/L); alkaline phosphatase 134u/L (35-120 u/L); magnesium 0.61 mmol/L (0.70-1.03 mmol/L); T4 27.9 pmol/ L (7.6-19.7 pmol/L); T3 1.9 pmol/L (1.5-3.0 pmol/L); TSH 0.02 mU/L (0.4-4.5 MU/L); parathyroid hormone <10 ng/L (10-50 ng/L). Full blood count, renal function and autoantibody screen...
متن کاملHypocalcemic generalised seizures as a manifestation of iatrogenic hypoparathyroidism months to years after thyroid surgery.
Hypoparathyroidism is a relatively common side effect of a thyroidectomy and leads to hypocalcemia. Carpopedal spasm and tetany are typical manifestations and usually occur within weeks after surgery. The first signs can be less typical and include movement disorders such as chorea, as well as symptoms of increased intracranial pressure or epileptic seizures. We describe two cases with generali...
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The aim of this study was to develop a derivative of chitosan as pharmaceutical excipient used in sustained-release matrix tablets of poorly soluble drugs. A water-soluble quaternary ammonium carboxymethylchitosan was synthesized by a two-step reaction with carboxymethylchitosan (CMCTS), decylalkyl dimethyl ammonium and epichlorohydrin. The elemental analysis showed that the target product with...
متن کاملPreparation, Characterization and in vivo Evaluation of Parenteral Sustained Release Microsphere Formulation of Zopiclone
The aim of this study was to prepare zopiclone-loaded polycaprolactone microspheres by emulsion solvent evaporation technique with different drug-to-carrier ratios {MP 1 (1:1), MP 2 (1:2), MP 3 (1:3), and MP 4 (1:4)}, characterize and evaluate the in vivo performance. The microspheres were characterized for particle size, surface morphology, drug excipient compatibility, percentage yield, drug ...
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ژورنال
عنوان ژورنال: BIO Web of Conferences
سال: 2017
ISSN: 2117-4458
DOI: 10.1051/bioconf/20170801012