Application of acoustic droplet vaporization in ultrasound therapy
نویسندگان
چکیده
منابع مشابه
Application of acoustic droplet vaporization in ultrasound therapy
Microbubbles have been used widely both in the ultrasonic diagnosis to enhance the contrast of vasculature and in ultrasound therapy to increase the bioeffects induced by bubble cavitation. However, due to their large size, the lifetime of microbubbles in the circulation system is on the order of minutes, and they cannot penetrate through the endothelial gap to enter the tumor. In an acoustic f...
متن کاملAcoustic Droplet Vaporization in Biology and Medicine
This paper reviews the literature regarding the use of acoustic droplet vaporization (ADV) in clinical applications of imaging, embolic therapy, and therapeutic delivery. ADV is a physical process in which the pressure waves of ultrasound induce a phase transition that causes superheated liquid nanodroplets to form gas bubbles. The bubbles provide ultrasonic imaging contrast and other functions...
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Acoustically sensitive emulsion droplets composed of a liquid perfluorocarbon have the potential to be a highly efficient system for local drug delivery, embolotherapy, or for tumor imaging. The physical mechanisms underlying the acoustic activation of these phase-change emulsions into a bubbly dispersion, termed acoustic droplet vaporization, have not been well understood. The droplets have a ...
متن کاملIn vivo microscopy of targeted vessel occlusion employing acoustic droplet vaporization.
OBJECTIVE Embolotherapy is a potential means to treat a variety of cancers. Our approach-gas embolotherapy-introduces the droplets upstream from the tumor and then acoustically activates them to form bubbles for occlusion-a process known as ADV. We wanted to provide the first optical documentation of ADV, lodged bubbles, or vessel occlusion in vivo. METHODS We used the rat cremaster muscle fo...
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Localized delivery of nucleic acids to target sites (e.g., diseased tissue) is critical for safe and efficacious gene therapy. An ultrasound-based technique termed acoustic droplet vaporization (ADV) has been used to spatiotemporally control the release of therapeutic small molecules and proteins contained within sonosensitive emulsions. Here, ADV is used to control the release of lipoplex-cont...
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ژورنال
عنوان ژورنال: Journal of Therapeutic Ultrasound
سال: 2015
ISSN: 2050-5736
DOI: 10.1186/s40349-015-0041-8