Application in silico Modeling Simulation in Bioequivalence Studies: A Review

Bioequivalence testing aims to ensure that the therapeutic performance of drug is consistent and reproducible when it administrated. Modeling simulation in silico methods are currently performed conduct virtual bioequivalence studies. Various computer software used generate model input data. This review summarizes for predicting vivo which supports analysis testing. GastroPlus™ SimCyp® widely platforms generating data The studies suggest validity procedure necessary modeling simulation. method has become a valuable tool as supporting extension biowaiver list contributing future development.