Apparent histological changes of adipocytes after treatment with CL 316,243, a ß-3-adrenergic receptor agonist
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منابع مشابه
Apparent histological changes of adipocytes after treatment with CL 316,243, a β-3-adrenergic receptor agonist
BACKGROUND AND OBJECTIVES The objective of this experiment was to study the effect of CL 316,243 (CL) (a highly selective β3-adrenergic receptor agonist) on cellular changes occurring in retroperitoneal white adipose tissue (RWAT) of lean and obese rats. METHODS Ten-month-old lean and obese Zucker rats were implanted subcutaneously with osmotic mini-pumps, infusing either saline or CL (1 mg/k...
متن کاملMechanisms of the antidiabetic effects of the b3-adrenergic agonist CL-316243 in obese Zucker-ZDF rats
Liu, Xilin, Fleurette Pérusse, and Ludwik J. Bukowiecki. Mechanisms of the antidiabetic effects of the b3adrenergic agonist CL-316243 in obese Zucker-ZDF rats. Am. J. Physiol. 274 (Regulatory Integrative Comp. Physiol. 43): R1212–R1219, 1998.—Previous studies have demonstrated that chronic cold exposure activates the sympathetic nervous system, increases energy expenditure, improves glucose tol...
متن کاملMechanisms of the antidiabetic effects of the β3-adrenergic agonist CL-316243 in obese Zucker-ZDF rats.
Previous studies have demonstrated that chronic cold exposure activates the sympathetic nervous system, increases energy expenditure, improves glucose tolerance, enhances insulin sensitivity, and stimulates glucose uptake in peripheral tissues [brown and white adipose tissues (BAT and WAT) and muscles] of normal rats. The goal of the present studies was to test whether the selective β3-adrenerg...
متن کاملMultilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes.
Multilocular, mitochondria-rich adipocytes appear in white adipose tissue (WAT) of rats treated with the beta3-adrenoceptor agonist, CL-316243 (CL). Objectives were to determine whether these multilocular adipocytes derived from cells that already existed in the WAT or from proliferation of precursor cells and whether new mitochondria contained in them were typical brown adipocyte mitochondria....
متن کاملEffect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice.
The antiobesity and antidiabetic effects of the beta3-adrenergic agonists were investigated on nonobese type 2 diabetic MKR mice after injection with a beta3-adrenergic agonist, CL-316243. An intact response to acute CL-316243 treatment was observed in MKR mice. Chronic intraperitoneal CL-316243 treatment of MKR mice reduced blood glucose and serum insulin levels. Hyperinsulinemic euglycemic cl...
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ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2015
ISSN: 1177-8881
DOI: 10.2147/dddt.s73891