Apoptotic and autophagic responses to Bcl-2 inhibition and photodamage
نویسندگان
چکیده
منابع مشابه
Apoptotic and Autophagic modulation by nicotine
Cigarette smoking is growing and nicotine is considered as the most adverse agent in the cigarette smoking. Nicotine is an alkaloid and forms 90% of alkaloids of cigarette. Nicotine is accountable for creating disorders and cancers such as lung cancer, heart disease and chronic lung disease. Nicotine can be considered as an autophagy and apoptosis inducer which can either directly or indirectly...
متن کاملApoptotic and Autophagic modulation by nicotine
Cigarette smoking is growing and nicotine is considered as the most adverse agent in the cigarette smoking. Nicotine is an alkaloid and forms 90% of alkaloids of cigarette. Nicotine is accountable for creating disorders and cancers such as lung cancer, heart disease and chronic lung disease. Nicotine can be considered as an autophagy and apoptosis inducer which can either directly or indirectly...
متن کاملTargeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals.
The antiapoptotic protein Bcl-2 inhibits Ca2+ release from the endoplasmic reticulum (ER). One proposed mechanism involves an interaction of Bcl-2 with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channel localized with Bcl-2 on the ER. Here we document Bcl-2-IP3R interaction within cells by FRET and identify a Bcl-2 interacting region in the regulatory and coupling domain of the IP3R....
متن کاملCombined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo
Despite great efforts taken to advance therapeutic measures for patients with glioblastoma, the clinical prognosis remains grim. The antiapoptotic Bcl-2 family protein Mcl-1 is overexpressed in glioblastoma and represents an important resistance factor to the BH-3 mimetic ABT263. In this study, we show that combined treatment with ABT263 and GX15-070 overcomes apoptotic resistance in establishe...
متن کاملThe Bcl-2-regulated apoptotic pathway.
Apoptosis (programmed cell death) is required for the removal of infected, damaged or unwanted cells and its disrupted regulation is implicated in cancer, autoimmunity and degenerative disorders. At the molecular level, multiple signaling pathways converge on a family of cysteine proteases (caspases), which when activated cause cellular destruction by cleaving a range of vital cellular substrat...
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ژورنال
عنوان ژورنال: Photochemical & Photobiological Sciences
سال: 2007
ISSN: 1474-905X,1474-9092
DOI: 10.1039/b707953b