Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders
نویسندگان
چکیده
منابع مشابه
Role of apolipoprotein E in neurodegenerative diseases
Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. APOE-dependent alterations of the endocytic pathway can affect different functions. APOE binds to cell-surface receptors to deliver lipids and to the hydrophobic amyloid-β peptide, regulating amyloid-β aggregations and clearances in the brain. Several APOE isoforms with major...
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This review examines the association between the apolipoprotein (apo) var epsilon gene polymorphism (or its protein product (apo E)), metabolic regulation of cholesterol, and cardiovascular disease. The apo var epsilon gene is located at chromosome 19q13.2. Among the variants of this gene, alleles (*) epsilon2, (*) epsilon3, and (*) epsilon4 constitute the common polymorphism found in most popu...
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Parkinson's disease and Huntington's disease are both model diseases. Parkinson's disease is the most common of several akinetic-rigid syndromes and Huntington's disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular biological studies have provided fascinating new insights into the pathogenesis of both disorders and t...
متن کاملNeurotoxic Fragments of Apolipoprotein E4 as a Biomarker for Alzheimer’s Disease and Other Neurodegenerative Disorders. INVENTORS
Apolipoprotein E (apoE) is the main transporter of cholesterol in the central nervous system (CNS) and is essential for neuronal maintenance and repair. ApoE polymorphisms in humans profoundly affect the structure and function of apoE and interfere with normal cellular metabolism. These polymorphisms arise from single-amino-acid substitutions at residues cys-112 and arg-158; among the three iso...
متن کاملCirculating Apolipoprotein E Concentration and Cardiovascular Disease Risk: Meta-analysis of Results from Three Studies
BACKGROUND The association of APOE genotype with circulating apolipoprotein E (ApoE) concentration and cardiovascular disease (CVD) risk is well established. However, the relationship of circulating ApoE concentration and CVD has received little attention. METHODS AND FINDINGS To address this, we measured circulating ApoE concentration in 9,587 individuals (with 1,413 CVD events) from three s...
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ژورنال
عنوان ژورنال: Journal of Molecular Medicine
سال: 2016
ISSN: 0946-2716,1432-1440
DOI: 10.1007/s00109-016-1427-y