منابع مشابه
The apolipoprotein CIII enhancer regulates both extensive histone modification and intergenic transcription of human apolipoprotein AI/CIII/AIV genes but not apolipoprotein AV.
The apolipoprotein (apo) AI/CIII/AIV/AV cluster genes are expressed at different levels in the liver and intestine. The apoCIII enhancer, a common regulatory element, regulates the tissue-specific expression of apoAI, apoCIII, and apoAIV but not apoAV. To study this regulation at the chromatin level, the histone modifications and intergenic transcription in the human apoAI/CIII/AIV/AV cluster w...
متن کاملPlasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels.
Apolipoprotein AV (apoAV) overexpression causes a decrease in plasma triglyceride (TG) levels, while deficiency of apoAV causes hypertriglyceridemia in both men and mice. However, contrary to what would be expected, plasma apoAV and TG levels in humans are positively correlated. To address this apparent paradox, we determined plasma apoAV levels in various mouse models with median TG levels ran...
متن کاملNewly identified apolipoprotein AV gene predisposes to high plasma triglycerides in familial combined hyperlipidemia.
vs the DCCT value of 1.26% Units. The two values for the mean bias shown in the EQAS by the VaII/a system ( 0.33% Units vs the DCCT assigned values and 0.02% Units vs the instrument’s median values) combined with a mean CV of 3% gave theoretical 95% confidence intervals for a single measurement of approximately 0.7% Units and 0.2% Units, respectively. Such values for the total error may be rega...
متن کاملNew variants in the apolipoprotein AV gene in individuals with extreme triglyceride levels.
Animal studies (on transgenic and knock-out mice) and human association analysis assessed the importance of APOAV gene for plasma triglyceride determination. New APOAV missense variants (Val153 --> Met and Cys185 --> Gly) have been detected recently. We have analyzed these variants in 83 unrelated patients with extreme lipid parameters (triglycerides of 20.4+/-2.8 mmol/l and total cholesterol o...
متن کاملApolipoprotein AV variants do not affect C-reactive protein levels in Caucasian males.
The important role of APOAV gene variants in determination of plasma triglyceride levels has been shown in many population studies. Recently, an influence of APOAV T-1131>C polymorphism on C-reactive protein (CRP) in young Korean males has been reported. We have therefore analyzed a putative association between T-1131>C, Ser19>Trp and Val153>Met APOAV variants (PCR and restriction analysis) and...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2005
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000193889.65915.f9