منابع مشابه
Apolipoprotein A-I mimetics and high-density lipoprotein function.
PURPOSE OF REVIEW To review recently published advances in the development of apolipoprotein A-I (apoA-I) mimetic peptides as a potential treatment for cardiovascular diseases. RECENT FINDINGS Various apoA-I mimetic peptides are currently in development and these display potent cardioprotective features that can rival or even surpass those of full length apoA-I and high-density lipoproteins (...
متن کاملApolipoprotein A-I Therapy
Since 1988, with the release of the National Cholesterol Education Panel (NCEP) Adult Treatment Panel I, lowdensity lipoprotein cholesterol (LDL-C) has been the primary focus of therapy (1). Although the total cholesterol to high-density lipoprotein cholesterol (HDL-C) ratio is a better cardiovascular risk predictor (2), the consensus at the time was that the clinical evidence only supported LD...
متن کاملApolipoprotein A-I mimetic peptides.
Despite identical amino acid composition, differences in class A amphipathic helical peptides caused by differences in the order of amino acids on the hydrophobic face results in substantial differences in antiinflammatory properties. One of these peptides is an apolipoprotein A-I (apoA-I) mimetic, D-4F. When given orally to mice and monkeys, D-4F caused the formation of pre-beta high-density l...
متن کاملApolipoprotein A-I mimetic peptides.
PURPOSE OF REVIEW To review published data related to the potential applicability of apolipoprotein A-I mimetic peptides. RECENT FINDINGS Despite a wealth of information on HDL-C levels and risk for cardiovascular disease (CVD), little evidence is present to suggest that raising HDL-C levels per se will result in CVD risk reduction. Rather, increasing HDL functionality might be a more success...
متن کاملApolipoprotein A-I and Cancer
High-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), the predominant protein in plasma HDL, have long been the focus of intense studies in the field of atherosclerosis and cardiovascular disease. ApoA-I, in large part, is responsible for HDL assembly and its main atheroprotective function, that of shuttling excess cholesterol from peripheral tissues to the liver for excretion (revers...
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ژورنال
عنوان ژورنال: Current Opinion in Lipidology
سال: 2014
ISSN: 0957-9672
DOI: 10.1097/mol.0000000000000092